Posts Tagged ‘first synthetic species’

While evoking images of Frankenstein-like scientific tinkering, this week J. Craig Venter of the Craig Venter Institute in Rockville, Md said,

We’re here to announce the first synthetic cell.

Venter told reporters that the new species — dubbed Mycoplasma mycoides JCVI-syn1.0 — is similar to one found in nature, but each cell is controlled only by a single million-base pair chromosome assembled from the bio-computer laboratory. The research is reported in the May 20 issue of Science.

The new species, Venter said, started with researchers digitizing the genetic code for the new species on computers, and then assembling the nucleotides using “four bottles of chemicals” into sections of DNA. The DNA sections were assembled in yeast cells to form a synthetic chromosome, which was then transferred to a related species of bacteria, M. capricolum.

Late in March, the researchers told reporters, the modified cells began replicating and formed a “blue colony” of the new species. Venter said,

This is the first self-replicating species that we’ve had on the planet whose parent is a computer.

Indeed, he and his colleagues consistently used computer language to describe the work. The new chromosome is like an operating system, they said, and it reprograms the M. capricolum cells to become M. mycoides.

The result comes after 15 years of research — and some $40 million — aimed at finding what Venter has called the minimal genome: the smallest set of genes that can support a living creature. But it could quickly have spinoffs, the researchers said.

This process has enormous commercial potential, including new tools for developing future vaccines, pharmaceuticals, biofuels, biochemicals, and perhaps synthetic algae to cope with oil spills such as the one currently threatening the Gulf Coast of the U.S.

Describing the new species as “synthetic” may be going too far, according to some experts. It’s “synthetic in the sense that its DNA is synthesized, not in that a new life form has been created,” according to molecular biologist Jim Collins of Boston University writing in the Nature. “Its genome is a stitched-together copy of the DNA of an organism that exists in nature, with a few small tweaks thrown in.”

Mark Bedauv of Reed College in Portland, Ore., also writing in the Nature commentary called the new species “a normal bacterium with a prosthetic genome.”

The prosthetic genome had some problems, however. Venter and colleagues were stalled for several months because one of the pieces of DNA they painstakingly crafted had a typo – a single base-pair deletion – that means the whole chromosome could not function.

“So accuracy is essential,” Venter said. “There’s parts of the genome where it can’t tolerate even a single error and there’s parts where we can put in large blocks of DNA and it can tolerate all kinds of errors.”

Molecular geneticist Georgia Purdom from Ohio State University noted that this kind of genetic engineering is “like taking the hard drive of computer #1 and putting it into computer #2 that has had its own hard drive removed. So effectively computer #2 becomes computer #1.”

Regardless of the inference to molecules-to-man evolution, even Venter noted that they “didn’t create life from scratch.”

Frances Arnold, synthetic biologist at the California Institute of Technology in Pasadena, emphasized “[w]e can write anything we want,” said Arnold. “The problem is that we don’t know what to write.”

This historical event highlights the fact that writing genetic information has an absolute requirement—intelligence with perfection.

Jonathan Wells of the Discovery Institute explains further what’s going on behind the headlines at Evolution News & Views: